Abstract: Bacterial infection is one of the leading causes of morbidity and mortality worldwide, and heavy burdens imposed by implant-related infection necessitate biomaterial with antibacterial properties. Silver, silicon co-substituted apatite (Ag,Si-HA) has been developed, integrating antibacterial properties yet retaining bioactivity in promoting bone regeneration. This study evaluates the antibacterial properties of Ag,Si-HA against P. aeruginosa at various populations of 104, 106 and 108 CFU/mL. Results demonstrated growth inhibition of P. aeruginosa at all populations after 24 h. In addition, the antibacterial efficacy of Ag,Si-HA at 104 CFU/mL P. aeruginosa was further examined by changing fresh population of P. aeruginosa to Ag,Si-HA at every 24 h over a period of 72 h. Despite continuous exposure to P. aeruginosa, Ag,Si-HA could inhibit the growth of P. aeruginosa, and this greatly demonstrated the potential of Ag,SiHA in exhibiting prolonged antibacterial efficacy during bone regeneration process.
Authors: P.N. Lim, B. Ho, and E.S. Thian
Keywords: Antibacterial, Apatite, Bone, Silicon, Silver